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Decrease in annexin I messenger ribonucleic acid expression in human amnion with labor.

D I Lynch-Salamon¹, W V Everson, L Myatt

¹Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, OH 45267-0526.

American Journal of Obstetrics and Gynecology

|December 1, 1992

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Labor significantly reduces annexin I protein and messenger RNA in human amnion. This decrease may elevate phospholipase A2 activity, contributing to prostaglandin production during childbirth.

Area of Science:

Biochemistry
Reproductive Biology
Molecular Genetics

Background:

Annexins are proteins that inhibit phospholipase A2, thereby reducing prostaglandin production.
Prostaglandins play a crucial role in the labor process.

Purpose of the Study:

To investigate if annexin I concentration decreases in human amnion during labor.
To determine if reduced annexin I messenger RNA (mRNA) expression mediates this decrease.

Main Methods:

Collected human amnion and choriodecidua from term pregnancies with and without labor.
Quantified annexin I protein using Western blotting.
Identified and quantified annexin I mRNA via Northern and slot blotting.

Main Results:

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Annexin I protein concentration was significantly lower in the labor group compared to the non-labor group.
Annexin I mRNA expression was also significantly reduced in the labor group.
A decrease in annexin I mRNA correlated with a decrease in annexin I protein.

Conclusions:

Labor is associated with a significant reduction in both annexin I mRNA and protein in human amnion.
This reduction may lead to increased phospholipase A2 activity, arachidonic acid mobilization, and prostaglandin production during labor.
Findings suggest a molecular mechanism linking annexin I levels to the onset and progression of human labor.