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Related Experiment Videos

Increased lymphatic pumping ability in pregnant ewes.

G J Valenzuela1, S Cheshier, G Hunt

  • 1Division of Perinatal Biology, Loma Linda University, CA.

American Journal of Obstetrics and Gynecology
|December 1, 1992
PubMed
Summary

Pregnancy increases lymphatic system pressure generation but decreases its breaking point, potentially explaining fluid retention. This study assessed lymphatic pumping ability in pregnant ewes.

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Area of Science:

  • Physiology
  • Lymphatic System Dynamics
  • Reproductive Physiology

Background:

  • The lymphatic system returns liters of fluid to circulation daily.
  • Lymphatic vessels pump fluid against a pressure gradient.
  • Systemic circulation vessels are hyporesponsive to vasoconstrictors during pregnancy.

Purpose of the Study:

  • To assess if lymphatic pumping ability decreases during pregnancy.
  • To investigate the impact of pregnancy on lymphatic system function.

Main Methods:

  • Chronic catheterization of the thoracic duct and jugular vein in pregnant ewes.
  • Measurement of lymph flow rate against varying outflow pressures.
  • Determination of "breaking point" and "stopflow" pressures.

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Main Results:

  • Pregnant ewes exhibited a significantly diminished breaking point (-1 +/- 2.7 mm Hg) compared to nonpregnant sheep (14.4 +/- 3.0 mm Hg).
  • Stopflow pressures were higher in pregnant ewes (62 +/- 7.3 mm Hg) versus nonpregnant (23.9 +/- 4.7 mm Hg).
  • Lymphatic system pressure generation capacity increased during pregnancy.

Conclusions:

  • Pregnancy enhances the lymphatic system's ability to generate pressure.
  • A diminished breaking point in lymphatic pumping during pregnancy was observed.
  • Altered lymphatic pumping may contribute to fluid retention in pathophysiological conditions.