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Related Experiment Videos

True histiocytic lymphoma (monocytic sarcoma)

C Soria1, J L Orradre, D García-Almagro

  • 1Department of Dermatology, Virgen de la Salud Hospital, Toledo, Spain.

The American Journal of Dermatopathology
|December 1, 1992
PubMed
Summary

True histiocytic lymphoma, a rare monocyte-macrophage tumor, presents as skin lesions. This study highlights CD68

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Area of Science:

  • Oncology
  • Dermatopathology
  • Hematopathology

Background:

  • Histiocytic lymphoma, previously termed malignant histiocytosis, is a rare neoplastic proliferation.
  • Most historical cases are now reclassified as B- or T-large cell lymphomas.
  • Genuine histiocytic lymphoma of monocyte-macrophage origin is exceptionally uncommon.

Observation:

  • Two cases of cutaneous genuine histiocytic lymphoma are presented.
  • Lesions were characterized by dense dermal infiltrates of mononuclear cells.
  • Immunophenotyping revealed CD11c and CD68 positivity, with negative T- and B-cell markers.

Findings:

  • Gene rearrangement studies showed germline configurations for T-cell receptor and immunoglobulin genes.
  • Neither peripheral blood nor bone marrow involvement was detected.

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  • Both patients achieved disease-free status after polychemotherapy.

    • Implications:

    • The CD68 marker is crucial for diagnosing true histiocytic lymphoma.
    • A therapeutic strategy similar to monocytic leukemia may be appropriate.
    • The term 'monocytic sarcoma' is proposed for this clinicopathological entity.