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Prolonged QT interval in alcoholic autonomic nervous dysfunction.

A Yokoyama1, H Ishii, T Takagi

  • 1Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.

Alcoholism, Clinical and Experimental Research
|December 1, 1992
PubMed
Summary
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Alcoholism worsens QT prolongation and autonomic nerve dysfunction, increasing sudden cardiac death risk. This study links impaired cardiac autonomic function (CVRR) to prolonged QTc intervals in alcoholic men.

Area of Science:

  • Cardiology
  • Autonomic Neuroscience
  • Clinical Electrophysiology

Background:

  • QT prolongation is a risk factor for sudden cardiac death.
  • Alcoholism is frequently associated with cardiac abnormalities, including QT prolongation.
  • Autonomic nervous system dysfunction may play a role in alcohol-related cardiac issues.

Purpose of the Study:

  • To investigate the relationship between QT prolongation and cardiac autonomic nerve function in alcoholics.
  • To assess if autonomic nervous dysfunction exacerbates QT prolongation in individuals with alcoholism.
  • To evaluate the impact of alcoholism on cardiac autonomic function and QT interval.

Main Methods:

  • Compared QT interval and coefficient of variation of the R-R interval (CVRR) in three groups: alcoholics with autonomic nervous dysfunction (AN), alcoholics without AN, and healthy controls.

Related Experiment Videos

  • Measured QTc interval and CVRR at rest after 30 days of abstinence, excluding subjects with confounding cardiac conditions.
  • Defined AN as CVRR < 80% of the standard predicted value.

    • Main Results:

    • Alcoholics showed a negative correlation between QTc interval and CVRR (r = -0.49, p < 0.0001).
    • QTc prolongation was significantly higher in alcoholics with AN (46.9%) compared to those without AN (21.9%, p < 0.05).
    • Alcoholics with AN had significantly longer QTc intervals (444 msec) than alcoholics without AN (426 msec) and controls (398 msec).

    Conclusions:

    • Alcoholism contributes to both autonomic nerve dysfunction and QT prolongation.
    • The combination of autonomic dysfunction and prolonged QTc in alcoholics may increase the risk of sudden cardiac death.
    • Cardiac autonomic function assessment is crucial in managing alcohol-related cardiac complications.