Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

MOCA induces membrane spreading by activating Rac1.

Kazuhiko Namekata1, Yasushi Enokido, Kazu Iwasawa

  • 1National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8551, Japan.

The Journal of Biological Chemistry
|January 14, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AlV<sub>3</sub>/Cu<sub>9</sub>Al<sub>4</sub> Composite Derived from Al-V-Cu Precursors for Enhancing the Hydrogen Storage Properties of MgH<sub>2</sub>.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Clonal Stabilization Reveals a DAO/3MST-Expressing MDCK Subpopulation With Robust d-Cysteine-Mediated H<sub>2</sub>S Production.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

The DOCK3-HAUS7 axis: A new paradigm in optic nerve regeneration.

Neural regeneration research·2026
Same author

Physiological Roles of Hydrogen Sulfide/Polysulfides and Regulation of their Production.

Handbook of experimental pharmacology·2026
Same author

Transcript Imbalance from TENM4 Exon Skipping: Effects on Epilepsy and Genetic Pleiotropy.

Molecular neurobiology·2025
Same author

Correlations between amyloid-β peptide levels in aqueous humor and retinal thickness in patients with glaucoma.

Scientific reports·2025

Modifier of cell adhesion protein (MOCA) regulates Rac1 activity, impacting cell shape and adhesion. Farnesylated MOCA enhances these effects, suggesting a role in cytoskeletal organization.

Area of Science:

  • Cell Biology
  • Neuroscience
  • Molecular Biology

Background:

  • Modifier of cell adhesion protein (MOCA), also known as Dock3, is a neuronal protein.
  • MOCA belongs to the Dock180 family and was initially identified as presenilin-binding protein (PBP).

Purpose of the Study:

  • To investigate the function of MOCA in regulating cell adhesion and morphology.
  • To determine MOCA's interaction with Rac1 and its downstream signaling pathways.

Main Methods:

  • Investigated MOCA's binding to Rac1 and its effect on Rac1 activity.
  • Analyzed the impact of farnesylated MOCA on Rac1 and JNK activation.
  • Examined MOCA localization in relation to actin filaments in neuronal growth cones and lamellipodia.

Related Experiment Videos

Main Results:

  • MOCA binds to and enhances Rac1 activity, leading to c-Jun NH(2)-terminal kinase (JNK) activation and altered cell morphology.
  • Farnesylated MOCA exhibits stronger enhancement of Rac1 and JNK activation, inducing flattened cell morphology.
  • Endogenous MOCA localizes with actin at the leading edge of lamellipodia and neuronal growth cones.

Conclusions:

  • MOCA regulates cytoskeletal organization and cell adhesion through modulation of Rac1 activity.
  • The findings suggest MOCA plays a significant role in neuronal development and cell migration.