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Related Experiment Videos

The acoustic startle reflex in ischemic stroke.

S K Jankelowitz1, J G Colebatch

  • 1Department of Neurology, Institute of Neurological Sciences, Prince of Wales Hospital, Sydney, Australia.

Neurology
|January 14, 2004
PubMed
Summary

Stroke and spinal cord injury patients often exhibit an increased acoustic startle response, particularly in the biceps muscle. Pontine lesions specifically correlate with symptomatic startle increases in these neurological conditions.

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Area of Science:

  • Neuroscience
  • Clinical Neurology

Background:

  • The acoustic startle response is a fundamental neurological reflex.
  • Understanding alterations in this reflex can provide insights into neurological damage.

Purpose of the Study:

  • To investigate the acoustic startle response in patients with stroke and incomplete cervical cord lesions.
  • To identify potential correlations between lesion location and startle response abnormalities.

Main Methods:

  • Recorded acoustic startle responses in 32 stroke patients, 6 spinal cord injury patients, and 26 healthy controls.
  • Assessed response magnitude in specific muscle groups, including biceps and tibialis anterior.

Main Results:

  • Approximately 25% of stroke and spinal cord injury patients showed an increased startle response.

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  • The biceps muscle exhibited the most significant deviations from normal startle responses.
  • Symptomatic increases in startle were exclusively observed in patients with pontine lesions.

    • Conclusions:

    • Increased acoustic startle response is a notable finding in a subset of stroke and spinal cord injury patients.
    • Segmental changes may contribute to altered startle responses in spinal cord injury.
    • Pontine lesions are specifically associated with symptomatic acoustic startle abnormalities.