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Serum lipoprotein(a) concentration and Apo(a) isoform under the condition of renal dysfunction

Miho Kuboyama1, Masato Ageta, Tabito Ishihara

  • 1Department of Internal Medicine, Miyazaki Prefectural Nichinan Hospital, Miyazaki, Japan. miho-k@miyazaki-catv.ne.jp

Journal of Atherosclerosis and Thrombosis
|January 14, 2004
PubMed

Insights

Chronic renal failure (CRF) patients exhibit elevated serum lipoprotein(a) (Lp(a)) levels, particularly those with high molecular weight apoprotein(a) (apo(a)) isoforms. Increased creatinine levels correlate with higher Lp(a) and HMW-apo(a) concentrations in CRF.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Clinical Chemistry

Background:

  • Serum lipoprotein(a) (Lp(a)) is a recognized independent risk factor for cardiac events.
  • Patients with chronic renal failure (CRF) commonly present with elevated serum Lp(a) concentrations.

Purpose of the Study:

  • To investigate the association between serum Lp(a) levels and apoprotein(a) (apo(a)) isoforms in patients with renal dysfunction.
  • To explore the relationship between Lp(a), apo(a) isoforms, and creatinine levels in a cohort with cardiovascular risk factors.

Main Methods:

  • Study included 130 patients with hypertension, hyperlipidemia, diabetes mellitus, and/or CRF.
  • Patients were stratified into two groups based on serum creatinine levels (CRF: Cr > 2.0 mg/dl; Controls: Cr < 1.2 mg/dl).
  • Serum Lp(a) concentration and apo(a) isoforms were analyzed in relation to renal function.

Main Results:

  • CRF patients demonstrated significantly higher serum Lp(a) concentrations compared to controls.
  • A high prevalence of high molecular weight (HMW)-apo(a) isoforms was observed in CRF patients.
  • Serum creatinine levels positively correlated with both HMW-apo(a) presence and serum Lp(a) concentration.

Conclusions:

  • Elevated serum Lp(a) in CRF is linked to specific apo(a) isoforms, particularly HMW variants.
  • Renal dysfunction, indicated by increased creatinine, is associated with higher Lp(a) and HMW-apo(a) levels.
  • These findings highlight the interplay between renal function, Lp(a), and cardiovascular risk in CRF patients.

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