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Chronic encephalitis (Rasmussen's syndrome) and ipsilateral uveitis.

A S Harvey1, F Andermann, I J Hopkins

  • 1Department of Neurology, Royal Children's Hospital, Melbourne, Australia.

Annals of Neurology
|December 1, 1992
PubMed
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Acute uveitis in children with Rasmussen's syndrome suggests a potential viral cause. The eye inflammation correlated with brain inflammation, hinting at ocular infection and neurotropic spread.

Area of Science:

  • Ophthalmology
  • Neurology
  • Pediatrics

Background:

  • Rasmussen's syndrome is a rare, chronic inflammatory brain disease affecting children.
  • It is characterized by progressive neurological decline, often unilateral.

Observation:

  • Two pediatric cases of acute uveitis during the early stages of Rasmussen's syndrome were documented.
  • Ocular inflammation was ipsilateral to the cerebral inflammation in both children.
  • One child also exhibited milder contralateral ocular inflammatory changes.

Findings:

  • The concurrent occurrence of uveitis and encephalitis in Rasmussen's syndrome was observed.
  • A strong correlation between the laterality of eye and brain inflammation was noted.

Implications:

Related Experiment Videos

  • This association supports the viral hypothesis for Rasmussen's syndrome.
  • It suggests the possibility of primary ocular infection with subsequent neurotropic spread to the brain.
  • Ophthalmological monitoring may be valuable in early-stage Rasmussen's syndrome.