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Risk for stroke after elective noncarotid vascular surgery
David A Axelrod1, James C Stanley, Gilbert R Upchurch
1Section of Vascular Surgery, Department of Surgery, Robert Wood Johnson Scholars Program, University of Michigan School of Medicine, University Hospital 2210D THCC/0329, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-0329, USA.
Insights
Stroke after noncarotid vascular surgery is rare but significantly increases mortality and hospital stay. Previous stroke history and illness severity are key risk factors, necessitating careful patient management.
Area of Science:
- Vascular Surgery
- Neurology
- Critical Care Medicine
Background:
- Patients with peripheral vascular disease often have systemic atherosclerosis, increasing stroke risk.
- The impact of cerebrovascular events on outcomes of noncarotid vascular surgery is not well understood.
Purpose of the Study:
- To determine the incidence of perioperative stroke after noncarotid peripheral vascular surgery.
- To identify independent risk factors for stroke.
- To quantify the effect of postoperative stroke on mortality and length of stay.
Main Methods:
- Analysis of data from the Veterans Affairs National Surgery Quality Improvement Project and patient treatment files (1997-2000).
- Inclusion of patients undergoing abdominal aortic aneurysmectomy, aortobifemoral bypass, lower extremity bypass, and major lower extremity amputation.
- Logistic and linear regression analyses to identify risk factors and assess the impact of stroke on mortality and length of stay.
Main Results:
- Stroke incidence ranged from 0.4% to 0.6% across procedures.
- Independent stroke risk factors included preoperative ventilation, prior stroke/transient ischemic attack, postoperative myocardial infarction, and return to the operating room.
- Postoperative stroke significantly increased perioperative mortality (OR, 6.3) and length of stay (48% increase).
Conclusions:
- Stroke is infrequent but serious after noncarotid peripheral vascular surgery.
- Previous stroke history and overall illness severity are primary stroke risk factors.
- Patients with these risk factors require focused assessment and management of modifiable risk factors.
Introduction:
Patients undergoing operations to treat peripheral vascular disease have systemic atherosclerosis and are at risk for stroke. However, the incidence and effect of cerebrovascular events on noncarotid vascular surgical outcomes are not well-defined.
Methods:
Patients undergoing common operations for vascular disease from 1997 to 2000 were examined with data from the Veterans Affairs (VA) National Surgery Quality Improvement Project and the VA patient treatment files. Operations studied included abdominal aortic aneurysmectomy (n = 2551), aortobifemoral bypass (n = 2616), lower extremity bypass (n = 6866), and major lower extremity amputation (n = 7442). The incidence of perioperative stroke was determined, and logistic regression analysis was used to identify independent risk factors for stroke. Logistic and linear regression analyses were used to quantify the effect of postoperative stroke on adjusted mortality and length of stay. Odds ratio (OR) and 95% confidence interval (CI) were defined. P <.05 was considered significant.
Results:
Stroke was uncommon after noncarotid vascular procedures, occurring in only 0.4% to 0.6% of patients. Independent risk factors for stroke include preoperative ventilation (OR, 11; 95% CI, 5.0-22.3; P <.001), previous stroke or transient ischemic attack (OR, 4.2; 95% CI, 2.7-6.4; P <.001), postoperative myocardial infarction (OR, 3.3; 95% CI, 1.3-8.7; P =.009), and need to return to the operating room (OR, 2.2; 95% CI, 1.4-3.5; P =.001). Factors that did not appear to be associated with stroke risk included procedure type, diabetes, renal failure, dialysis dependence, number of transfused units of blood, and hypertension. After controlling for other postoperative complications and comorbid conditions, postoperative stroke significantly increased the risk for perioperative mortality (OR, 6.3; 95% CI, 3.4-11.4; P <.001), with similar magnitude as postoperative myocardial infarction (OR, 6.3; 95% CI, 3.9-10.1; P <.001). Stroke was also associated with a 48% increase in overall length of stay.
Conclusions:
Stroke after noncarotid peripheral vascular surgery is uncommon, but results in markedly increased mortality and length of stay. Stroke risk is most strongly associated with previous stroke history and greater degree of illness. Patients with these associated conditions deserve particular attention to assessing and medically managing modifiable risk factors.
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