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Related Experiment Videos

Foregut motor function in chronic renal failure.

A M Ravelli1, S E Ledermann, W M Bisset

  • 1Medical Unit, Institute of Child Health, London.

Archives of Disease in Childhood
|November 1, 1992
PubMed
Summary
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Children with chronic renal failure (CRF) often experience anorexia and vomiting due to foregut motility disorders. These issues, including reflux and delayed gastric emptying, are linked to CRF

Area of Science:

  • Pediatric Nephrology
  • Gastroenterology
  • Physiology

Background:

  • Anorexia, nausea, and vomiting are common in children with chronic renal failure (CRF).
  • The underlying mechanisms for these symptoms in pediatric CRF patients remain poorly understood.
  • Foregut motility disorders are suspected contributors to these gastrointestinal issues.

Purpose of the Study:

  • To investigate esophageal and gastric motor function in children with severe CRF experiencing anorexia and vomiting.
  • To identify specific motility abnormalities contributing to gastrointestinal symptoms in this population.
  • To explore the relationship between CRF and foregut motor function.

Main Methods:

  • Studied 12 children (7 months-6.8 years) with severe CRF not on dialysis, presenting with anorexia and vomiting.

Related Experiment Videos

  • Assessed gastro-oesophageal reflux using reflux index.
  • Measured gastric emptying times (T1/2) for glucose and milk meals.
  • Analyzed gastric antral electrical control activity.
  • Measured fasting serum gastrin concentrations.

    • Main Results:

    • Eight of 12 patients exhibited significant gastro-oesophageal reflux (mean reflux index 11.3%).
    • Seven of 10 patients showed altered gastric half emptying times for glucose and milk.
    • Gastric antral electrical control activity was abnormal in 6/11 patients, indicating gastric dysrhythmias.
    • Fasting serum gastrin concentrations were elevated in 7/9 patients (mean 168 pmol/l).
    • All studied CRF patients presented with at least one foregut motility disorder.

    Conclusions:

    • Children with chronic renal failure and persistent anorexia/vomiting exhibit significant foregut motility disorders.
    • Observed abnormalities include gastro-oesophageal reflux, delayed gastric emptying, and gastric dysrhythmias.
    • Elevated serum gastrin levels and the variety of motor disorders suggest that the CRF environment impacts foregut smooth muscle function.