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Orofacial granulomas after injection of cosmetic fillers. Histopathologic and clinical study of 11 cases
T Lombardi1, J Samson, F Plantier
1Laboratory of Histopathology, Division of Stomatology, Faculty of Medicine, University of Geneva, Switzerland. Tommaso.Lombardi@medecine.unige.ch
Background:
Purposely, cosmetic injections in orofacial tissues of various resorbable, biodegradable, or permanent fillers may be followed by development of foreign-body granulomas. The aim of this article is to contribute to the histologic identification of the filler material.
Methods:
Histologic and clinical features of 11 cases of granulomas on orofacial fillers are described.
Results:
Only 3/11 patients knew the nature of the injected product. Four histologic patterns were found: (i) Artecoll, (ii) Dermalive, and (iii) New-Fill granuloma, all three of the classic giant cell granuloma type, differing in respect of foreign particles; and (iv) Liquid Silicone granuloma, which featured a cystic and macrophagic type. Information was often missing or misleading, patients or practitioners being reluctant to give the details.
Conclusion:
Increasing demand for orofacial tissue augmentation makes pathologists face new, and sometimes, puzzling granuloma types. Identification of the foreign product might be required for therapeutic or medico-legal reasons.
