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Related Experiment Videos

Asthma is associated with single-nucleotide polymorphisms in ADAM33.

M Werner1, N Herbon, H Gohlke

  • 1Institute of Epidemiology, GSF National Research Center for Environment and Health, Ingolstaedter Landstrasse, Neuherberg, Germany. m@wjst.de

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|January 15, 2004
PubMed
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Genetic variants in the ADAM33 gene are linked to asthma and bronchial hyper-reactivity. This study confirms the association in German populations, identifying specific single-nucleotide polymorphisms (SNPs) related to asthma risk.

Area of Science:

  • Genetics
  • Pulmonology
  • Molecular Biology

Background:

  • The ADAM33 gene, encoding a metalloproteinase, is implicated in asthma and bronchial hyper-reactivity.
  • ADAM33 plays a role in intra- and extracellular signaling pathways through protein shedding.

Purpose of the Study:

  • To investigate the association between ADAM33 gene polymorphisms and asthma in two distinct German populations.
  • To identify specific single-nucleotide polymorphisms (SNPs) within ADAM33 linked to asthma and related respiratory traits.

Main Methods:

  • Genotyping of 15 intragenic SNPs using MALDI-TOF mass spectrometry.
  • Association analysis employing the transmission disequilibrium test in a German asthma family study.
  • Case-control association testing using Armitage's trend test in the European Community Respiratory Health Study.

Related Experiment Videos

Main Results:

  • Significant associations between specific ADAM33 SNPs and asthma were found in both German study cohorts.
  • SNPs F+1, ST+4, and ST+5 showed significant association in the family study (lowest P=0.005 for F+1).
  • SNP ST+7 was significantly associated with asthma in the case-control study (P=0.008), with some SNPs also linked to IgE levels and bronchial hyper-responsiveness.

Conclusions:

  • This study replicates the association between ADAM33 gene variants and asthma.
  • Discrepancies in associated SNP positions across German, UK, and US samples suggest potential complexity.
  • The exact causal variants within or near ADAM33 responsible for the observed asthma association remain to be identified.