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Mycobacterium tuberculosis Beijing genotype.

Troels Lillebaek1, Ase B Andersen, Asger Dirksen

  • 1National Institute for Prevention and Control of Infectious Diseases and Congenital Disorders, Copenhagen, Denmark. tll@ssi.dk

Emerging Infectious Diseases
|January 15, 2004
PubMed
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The Beijing family of Mycobacterium tuberculosis strains, linked to severe tuberculosis, was found in 2.5% of Danish patients (1992-2001). No increase over time or historical presence was detected in this population-based study.

Area of Science:

  • Epidemiology
  • Microbiology
  • Genetics

Background:

  • The Beijing family of Mycobacterium tuberculosis strains is globally significant due to its association with tuberculosis outbreaks, increased virulence, and multidrug resistance.
  • Understanding the prevalence and spread of specific Mycobacterium tuberculosis strains, like the Beijing family, is crucial for public health interventions.

Purpose of the Study:

  • To conduct the first population-based investigation of Beijing strains within the Danish DNA fingerprint database.
  • To determine the prevalence of Beijing strains among tuberculosis patients in Denmark between 1992 and 2001.

Main Methods:

  • Analysis of 97% of all culture-positive tuberculosis cases in Denmark from 1992 to 2001.
  • Utilized the Danish DNA fingerprint database for strain identification.

Related Experiment Videos

  • Compared findings with historical data from Danish-born patients sampled in the 1960s.

    • Main Results:

    • Beijing strains were identified in 2.5% of all 3,844 tuberculosis patients studied.
    • Prevalence was 1.0% among Danish-born patients and 3.6% among immigrants from 85 countries.
    • No Beijing strains were detected in Danish-born patients from the 1960s, and no temporal increase was observed.

    Conclusions:

    • The Beijing strain of Mycobacterium tuberculosis is present in Denmark, primarily among immigrant populations.
    • There is no evidence of an increasing trend or historical presence in the Danish-born population during the study period.
    • The global prevalence of Beijing strains remains uncertain due to limited population-based analyses worldwide.