Related Experiment Video
Updated: Aug 29, 2026

Analysis of Cardiac Chamber Development During Mouse Embryogenesis Using Whole Mount Epifluorescence
Published on: April 17, 2019
Molecular regulation of cardiac chamber-specific gene expression
1Department of Cell Biology and Anatomy, University of Arizona Health Sciences Center, 1501 N. Campbell Avenue, Tucson, AZ 85724-5044, USA.
Abstract:
This review focuses on recent studies investigating the genetic regulatory mechanisms leading to formation of morphologically, functionally, and molecularly distinct cardiac chambers. The regulation of four representative chamber-specific genes that have been studied in detail is reviewed. These genes include the atrial-specific genes, myosin light chain-2a (MLC2a), slow myosin heavy chain-3 (slow MyHC3), and atrial natriuretic factor (ANF) and the ventricular specific gene, myosin light chain-2v (MLC2v). Comparison of these promoters reveals some generalizations about the regulatory mechanisms involved in chamber-specific gene expression but, equally, indicates the large gaps in the knowledge concerning this intriguing genetic program.
Related Concept Videos
Master Transcription Regulators
G-Protein Gated Ion Channels
Sensory organs,...
Cell Specific Gene Expression
Cell Specific Gene Expression
General Transcription Factors
Regulation of Expression at Multiple Steps

