[Synthesis of new pyrimidine 5'-H-thiophosphonates]

Thymidine and 3'-deoxythymidine 5'-H-thiophosphonates were synthesized by interaction of 3'-O-acetylthymidine or 3'-deoxythymidine and ammonium phosphinate in the presence of pivaloyl chloride and following oxidation in situ by sulfur of the intermediate phosphinates. The compounds seemed to be 1:1 mixture of diastereomers with chiral phosphorus. The prepared compounds were tested as potential inhibitors of HIV production.