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Related Experiment Videos

Auranofin-induced vasomotor reaction.

S M Proudman1, L G Cleland

  • 1Rheumatology Unit, Royal Adelaide Hospital, South Australia.

Arthritis and Rheumatism
|December 1, 1992
PubMed
Summary

Vasomotor reactions are known with gold injections but not oral gold. This case study reports a rheumatoid arthritis patient experiencing these reactions with both injectable gold sodium thiomalate and oral auranofin.

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Area of Science:

  • Rheumatology
  • Pharmacology
  • Clinical Medicine

Background:

  • Gold compounds are used to treat rheumatoid arthritis.
  • Injectable gold sodium thiomalate (GST) is known to cause vasomotor reactions.
  • Vasomotor reactions associated with oral gold compounds are not well-documented.

Observation:

  • A patient with rheumatoid arthritis was treated with gold compounds.
  • The patient experienced nitritoid reactions during treatment.
  • These reactions occurred with both injectable gold sodium thiomalate and oral auranofin.

Findings:

  • The patient exhibited typical nitritoid reactions.
  • These reactions were observed with both injectable and oral gold formulations.
  • This suggests a potential for vasomotor reactions with oral gold therapy.

Implications:

  • Vasomotor reactions may occur with oral gold treatment, not just injectable forms.
  • Clinicians should be aware of this possibility when prescribing oral gold.
  • Further investigation into the mechanisms of oral gold-induced vasomotor reactions is warranted.

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