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Ankylosing spondylitis in Rochester, Minnesota, 1935-1989. Is the epidemiology changing?

L D Carbone1, C Cooper, C J Michet

  • 1Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, Minnesota 55905.

Arthritis and Rheumatism
|December 1, 1992
PubMed
Summary

Ankylosing spondylitis incidence and clinical presentation remained consistent between 1935 and 1989. This study found no decrease in patient survival, suggesting prior findings of changes may be due to study biases.

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Area of Science:

  • Rheumatology
  • Epidemiology
  • Clinical Medicine

Background:

  • Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the axial skeleton.
  • Understanding temporal trends in AS incidence, clinical features, and survival is crucial for public health and clinical management.

Purpose of the Study:

  • To investigate trends in ankylosing spondylitis incidence and clinical presentation.
  • To assess survival rates among diagnosed patients.
  • To analyze data from Rochester, Minnesota residents diagnosed between 1935 and 1989.

Main Methods:

  • A population-based descriptive study design was employed.
  • Data collection spanned a 55-year period, from 1935 to 1989.
  • Age- and sex-adjusted incidence rates were calculated.

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Main Results:

  • The overall age- and sex-adjusted incidence rate of ankylosing spondylitis was 7.3 per 100,000 person-years.
  • A declining trend in incidence was observed from 1935 to 1989.
  • Little change was noted in the age of symptom onset or diagnosis, and overall survival was not decreased up to 28 years post-diagnosis.

Conclusions:

  • Epidemiologic characteristics of ankylosing spondylitis demonstrate constancy over time.
  • Previous reports of changing trends may be attributed to patient selection and study design biases.
  • These findings emphasize the stability of AS epidemiology in the studied population.