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Chordoma cutis.

Vinicio Boneschi1, Athanasia Tourlaki, Antonina Parafioriti

  • 1Institute of Dermatology, University of Milan, IRCCS Ospedale Maggiore, via Pace 9, 20122 Milan, Italy. vboneschi@hotmail.com

European Journal of Dermatology : EJD
|January 15, 2004
PubMed
Summary
This summary is machine-generated.

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This case study details a rare instance of a sacrococcygeal chordoma presenting as a skin tumor in an 85-year-old man. The findings highlight skin lesions as a potential early indicator of this spinal axis malignancy.

Area of Science:

  • Oncology
  • Dermatology
  • Pathology

Background:

  • Chordomas are rare, slow-growing malignant tumors arising from notochordal remnants, typically along the spinal axis.
  • Cutaneous manifestations of chordoma are uncommon, making early diagnosis challenging.

Observation:

  • An 85-year-old male with diffuse psoriasis presented with a large, asymptomatic subcutaneous tumor in the sacrococcygeal region.
  • The tumor exhibited a glistening, friable surface on cut section.
  • Histopathology revealed infiltration of the deep dermis by pleomorphic cells in cords and nests within a mucinous stroma, featuring characteristic physaliphorous cells.

Findings:

  • Immunohistochemical analysis showed neoplastic cells positive for cytokeratins, vimentin, S100 protein, and epithelial membrane antigen (EMA).

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  • The cells were negative for carcinoembryonic antigen (CEA).
  • Combined histological and immunohistochemical features confirmed the diagnosis of classic chordoma.

    • Implications:

    • This case underscores the importance of considering chordoma in the differential diagnosis of subcutaneous tumors, even with atypical presentations.
    • Skin lesions can occasionally be the initial presentation of primary or metastatic chordoma.
    • Increased awareness among clinicians regarding cutaneous chordoma may improve diagnostic timelines and patient outcomes.