Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet function after off pump coronary surgery.

Benjamin P Bidstrup1, Helen Scarrott, Monica Luque

  • 1James Cook University, Townsville, The Townsville Hospital, Douglas, Queensland, Australia. benjamin.bidstrup@bigpond.com

The Heart Surgery Forum
|January 15, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pharmacokinetic Similarity of Biosimiliar AVT05 Versus Reference Product Golimumab in Healthy Adults: A Double-Blind, Three-Arm, Parallel-Group Study.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy·2025
Same author

Efficacy and Safety of Biosimilar AVT05 Versus Reference Product Golimumab in Combination with Methotrexate in Moderate-to-Severe Rheumatoid Arthritis: 52-Week Results of a Randomized, Parallel-Group, Double-Blind Study.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy·2025
Same author

Effects of the affinity to the Mediterranean diet pattern together with breastfeeding on the incidence of childhood asthma and other inflammatory and recurrent diseases.

Allergologia et immunopathologia·2021
Same author

Blood transfusion: the epidemic continues.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2012
Same author

Reduction of post-surgical pericardial adhesions using a pig model.

Heart, lung & circulation·2011
Same author

Aprotinin and tranexamic acid in high-transfusion-risk cardiac surgery.

Transfusion·2006

Off-pump coronary artery bypass (OPCAB) surgery appears to improve platelet function, contrary to concerns about thrombotic complications. This pilot study suggests enhanced platelet activity post-OPCAB, warranting further investigation into perioperative antiplatelet strategies.

Area of Science:

  • Cardiovascular Surgery
  • Hematology
  • Platelet Physiology

Background:

  • The impact of off-pump coronary artery bypass (OPCAB) on platelet function remains largely unknown.
  • Concerns exist regarding potential thrombotic complications due to altered platelet function after OPCAB.
  • A pilot study was conducted to evaluate platelet function changes following OPCAB using a point-of-care test.

Purpose of the Study:

  • To assess the effect of OPCAB on platelet function.
  • To investigate whether OPCAB influences thrombotic processes.
  • To utilize the Hemostatus point-of-care test for platelet function assessment.

Main Methods:

  • Analysis of platelet function in 11 adult patients undergoing coronary artery bypass (CAB) surgery.
  • Platelet function assessment performed before OPCAB (pre-heparin) and after protamine reversal.

Related Experiment Videos

  • Utilized the Hemostatus test (Medtronic) for point-of-care platelet function evaluation.

    • Main Results:

    • Significant improvement in platelet function was observed, as measured by channels 5 and 6 of the Hemostatus test.
    • Mean blood loss in the first 24 hours was 598 ± 244 mL.
    • Only one patient required blood product transfusion.

    Conclusions:

    • Platelet function is improved, not diminished, after OPCAB surgery.
    • Potential mechanisms include the release of younger, larger platelets from bone marrow.
    • Findings have implications for perioperative antiplatelet agent management and suggest the need for further research.