Related Experiment Video

Updated: Aug 15, 2026

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
19:57

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings

Published on: March 30, 2014

Improving drug safety monitoring

Sunil Karande1, Nithya J Gogtay, Nilima A Kshirsagar

  • 1Department of Pediatrics, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai 400022, India.

Indian Pediatrics
|January 15, 2004
PubMed

Insights

Pediatric drug safety is crucial. Factors like young age and critical illness increase adverse drug reactions, necessitating enhanced monitoring systems for child safety.

Area of Science:

  • Pediatric Pharmacology
  • Drug Safety and Pharmacovigilance
  • Clinical Pharmacy

Background:

  • Adverse drug reactions (ADRs) pose significant risks to children.
  • Pediatric patients are vulnerable due to factors like young age, polypharmacy, critical illness, and off-label drug use.
  • The evolving healthcare landscape, including HIV/AIDS, intensive care units, advanced imaging, and new therapeutics, heightens the need for robust pediatric drug safety.

Purpose of the Study:

  • To highlight the critical importance of drug safety monitoring in pediatric populations.
  • To identify key risk factors associated with adverse drug reactions in children.
  • To advocate for improved drug safety surveillance systems in pediatric care.

Main Methods:

  • Review of identified risk factors for adverse drug reactions in children.
  • Analysis of the impact of national health trends on pediatric drug safety needs.
  • Proposal for enhanced drug safety monitoring strategies.

Main Results:

  • Young age, polypharmacy, prolonged hospitalization, critical illness, and use of unlicensed/off-label drugs are significant risk factors for pediatric ADRs.
  • The prevalence of HIV/AIDS, advanced intensive care, and new medical interventions underscore the urgency for improved pediatric drug safety.
  • Current systems require enhancement to adequately protect children from potential drug-related harm.

Conclusions:

  • Establishing in-hospital computerized event monitoring programs in major pediatric facilities is essential.
  • Developing an effective national post-marketing drug surveillance network is crucial for comprehensive pediatric drug safety.
  • Proactive and systematic drug safety monitoring is imperative to minimize adverse events in children.

More Related Videos

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry10:17

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

Related Concept Videos

Drug Regulation01:25

Drug Regulation

Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
Pharmacovigilance01:19

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
Therapeutic Drug Monitoring: Overview and Classification01:16

Therapeutic Drug Monitoring: Overview and Classification

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood at designated intervals to ensure the drug concentration stays within a therapeutic range. This monitoring is crucial for optimizing individual dosage regimens, enhancing therapeutic efficacy, and minimizing drug-related toxicity. TDM is vital for drugs with narrow therapeutic windows, significant variability in pharmacokinetics, and a clear correlation between plasma levels and...
Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
Therapeutic Drug Monitoring: Drug Analysis Methods01:26

Therapeutic Drug Monitoring: Drug Analysis Methods

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...