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CSF Glucose Concentrations in Infants with Febrile Convulsions and the Possible Effect of Acetaminophen

Mahmoud Mohammadi1, Mohammad R Mohebbi, Fariba Naderi

  • 1Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. mohamadi@sina.tums.ac.in

Indian Pediatrics
|January 15, 2004
PubMed

Insights

Acetaminophen affects the relationship between cerebrospinal fluid glucose and body temperature in infants. Febrile infants had higher CSF glucose levels than afebrile infants.

Area of Science:

  • Pediatrics
  • Neurology
  • Biochemistry

Background:

  • Febrile seizures are common in infants.
  • Cerebrospinal fluid (CSF) glucose levels can be affected by various factors, including fever and medication.
  • Understanding these relationships is crucial for diagnosis and management.

Purpose of the Study:

  • To investigate the correlation between CSF glucose concentration, body temperature, seizure duration, and acetaminophen use in infants.
  • To determine how acetaminophen administration influences the relationship between CSF glucose and body temperature.

Main Methods:

  • Retrospective record review of 117 febrile convulsive infants (3-18 months).
  • Analysis of CSF glucose concentration, body temperature, seizure duration, and acetaminophen administration.
  • Statistical correlation and comparison between groups (acetaminophen vs. no acetaminophen, febrile vs. afebrile).

Main Results:

  • A positive correlation was found between CSF glucose and body temperature in infants not given acetaminophen (r = 0.515).
  • CSF glucose levels were significantly higher in febrile infants (75.33 mg/dL) compared to afebrile infants (66.16 mg/dL).
  • In infants who received acetaminophen, a negative correlation existed between CSF glucose and body temperature (r = -0.389).

Conclusions:

  • Acetaminophen administration alters the relationship between CSF glucose and body temperature in infants.
  • Febrile infants generally exhibit higher CSF glucose levels.
  • Seizure characteristics like duration and multiplicity did not significantly correlate with CSF glucose levels.

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