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Related Experiment Videos

Gatifloxacin and prolonged QT interval.

Shoaib R Ansari1, Nagesh Chopra

  • 1Department of Internal Medicine, Morristown Memorial Hospital, NJ, USA. shoaib.r.ansari@uth.tmc.edu

The American Journal of the Medical Sciences
|January 15, 2004
PubMed
Summary

A patient taking gatifloxacin for sinusitis experienced syncope due to a prolonged QT interval. Stopping the antibiotic resolved the prolonged QT interval, suggesting gatifloxacin as the cause.

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Area of Science:

  • Pharmacology
  • Cardiology
  • Internal Medicine

Background:

  • Gatifloxacin is a fluoroquinolone antibiotic.
  • QT interval prolongation is a risk factor for serious cardiac arrhythmias.
  • Syncope can be a symptom of cardiac events.

Purpose of the Study:

  • To report a case of syncope associated with gatifloxacin-induced QT interval prolongation.
  • To highlight the potential cardiac risks of gatifloxacin.

Main Methods:

  • Case report of a 54-year-old woman.
  • Clinical observation of syncope and electrocardiogram (ECG) findings.
  • Monitoring of QT interval before, during, and after gatifloxacin treatment.

Main Results:

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  • The patient presented with syncope during gatifloxacin treatment for acute sinusitis.
  • Electrocardiogram revealed a markedly prolonged QT interval.
  • Discontinuation of gatifloxacin led to normalization of the QT interval.

Conclusions:

  • Gatifloxacin may cause significant QT interval prolongation.
  • This prolongation can lead to ventricular arrhythmias and syncope.
  • Caution is advised when prescribing gatifloxacin, especially in patients with cardiac risk factors.