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Primary cardiac T-cell lymphoma
Riccardo Giunta1, Ranieri G Cravero, Gianluca Granata
1Division of Internal Medicine, Allergy and Clinical Immunology, Department of Gerontology, Geriatrics and Metabolic Diseases, Second University of Naples School of Medicine, Italy.
Insights
Primary cardiac lymphoma (PCL) is rare in immunocompetent patients. This report details a T-cell PCL case, highlighting its rarity and diagnostic challenges.
Area of Science:
- Cardiology
- Oncology
- Pathology
Background:
- Primary cardiac lymphoma (PCL) is a rare malignancy.
- It often mimics cardiac disease in immunocompetent individuals.
- PCL typically involves the intrapericardial space.
Observation:
- Clinical symptoms include chest pain, arrhythmias, pericardial effusion, and heart failure.
- Diagnosis can be challenging, sometimes requiring invasive procedures or autopsy.
- Most reported PCL cases are of B-cell origin.
Findings:
- This report presents a rare case of T-cell primary cardiac lymphoma in an adult.
- This is only the second documented case of T-cell PCL in an immunocompetent patient.
- The study provides an overview of previously reported PCL cases.
Implications:
- Highlights the importance of considering rare T-cell lymphomas in cardiac diagnoses.
- Emphasizes diagnostic challenges and the need for advanced investigations.
- Contributes to understanding the spectrum of primary cardiac tumors.
Abstract:
Primary cardiac lymphoma (PCL), defined as a lymphoma clinically mimicking cardiac disease, with the bulk of the tumor located intrapericardially, is extremely rare in immunocompetent patients. Clinical manifestations vary depending on sites of involvement in the heart and include chest pain, arrhythmias, pericardial effusion, and heart failure. Diagnosis is often difficult and may require invasive procedures; in some cases, diagnosis is not made until autopsy. Histologically, nearly all cases of PCL reported thus far have been of B-cell origin. In this report, we describe a case of PCL of T-cell origin in an adult immunocompetent patient, the second reported in the literature to the best of our knowledge, and provide a brief overview of the features of previously published PCL cases.
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