[Modern principals of antibacterial therapy of suppurative-septic diseases]

The carried out researches concerning initial nidus of infection have shown a high rate of anaerobic infection especially in patients with destructive-suppurative lung disease, liver abscess, peritonitis (up to 82.8%). An aerobic-anaerobic association of microbes remarkably often is found in the nidus of infection. We recommend the following preventive scheme to treat patients with different pyoseptic diseases. The scheme is based on the results of our 10 years experience treatment of such patients. It consists of a combination of 2.0 gr. cefoperazoli twice daily, metronidasoli 500 mg. 3 times and amycacini 500 mg twice daily. The intra-arterial or intravenous introduction of the medications was possibly preferred. Having analyzed the results of the treatment of 13,747 patients treated at the center of contaminated surgery, we would note that in 30.2% of the cases were reached excellent results. The above-mentioned scheme of antibacterial therapy with surgical correction of suppurative focus allowed us to reach good results in 45.4%. The satisfactory results of the treatment were achieved in 22.8% of patients. Mortality rate was up to 1.9%.