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Subependymal giant cell astrocytoma with positive tuberin expression--case report
Sadaharu Tabuchi1, Haruo Takigawa, Akira Oka
1Department of Neurosurgery, Institute of Neurological Sciences, Tottori University School of Medicine, Yonago, Tottori, Japan. stabuchi@gj8.so-net.ne.jp
Neurologia Medico-Chirurgica
|January 16, 2004
Abstract:
An 11-year-old male presented with subependymal giant cell astrocytoma (SEGA) without other manifestations of tuberous sclerosis such as facial angiofibroma, epilepsy, or mental retardation. The diagnosis was "possible tuberous sclerosis complex" (TSC). Total resection of the tumor was performed. Immunohistochemical study revealed positive tuberin expression. In general, loss of tuberin is thought to be critical to the TSC phenotype. Our case demonstrated clear expression of tuberin in the SEGA specimen.