Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Accuracy limitations of chronaxie values.

Leslie A Geddes1

  • 1Department of Biomedical Engineering, Purdue University, West Lafayette, IN 47907-1296, USA. geddes@ecn.purdue.edu

IEEE Transactions on Bio-Medical Engineering
|January 16, 2004
PubMed
Summary

Understanding the strength-duration curve is key to studying excitable tissues. This research identifies factors affecting chronaxie measurement accuracy, recommending rectangular pulses from constant-current sources for reliable results.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Conduction of electrical current to and through the human body: a review.

Eplasty·2009
Same author

Methods for calculating coronary perfusion pressure during CPR.

Cardiovascular engineering (Dordrecht, Netherlands)·2009
Same author

Loose cuff hypertension.

Cardiovascular engineering (Dordrecht, Netherlands)·2009
Same author

An optical oscillometric method for neonatal and premature infant blood pressure monitoring.

Advances in neonatal care : official journal of the National Association of Neonatal Nurses·2009
Same author

Is there an alternative to mouth-to-mouth breathing?

The American journal of emergency medicine·2008
Same author

Electrophysiology of connection current spikes.

Cardiovascular engineering (Dordrecht, Netherlands)·2008

Area of Science:

  • Electrophysiology
  • Biophysics
  • Neuroscience

Background:

  • The strength-duration curve models the relationship between stimulus intensity and duration for tissue excitation.
  • Key parameters include rheobase (minimum current) and chronaxie (time constant).
  • Existing chronaxie values show significant variability across studies and tissue types.

Purpose of the Study:

  • To identify factors influencing the accuracy of chronaxie measurements.
  • To establish optimal conditions for reliable chronaxie determination.
  • To provide a basis for more consistent electrophysiological research.

Main Methods:

  • Analysis of factors affecting chronaxie measurement accuracy.
  • Comparison of different stimulus waveforms and delivery methods.
  • Evaluation of constant-current vs. constant-voltage stimulation.

Main Results:

  • Five key factors influencing chronaxie measurement accuracy were identified.
  • Rectangular pulse stimuli demonstrated higher reliability.
  • Constant-current sources yielded more consistent chronaxie values compared to constant-voltage sources.

Conclusions:

  • Chronaxie measurement accuracy is sensitive to several experimental parameters.
  • Using rectangular pulses from a constant-current source is recommended for precise chronaxie determination.
  • Standardizing measurement techniques will improve the comparability of electrophysiological data.

Related Experiment Videos