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Rowell's syndrome and associated antiphospholipid syndrome
D Pandhi1, A Singal, P Agarwal
1Department of Dermatology and STD, University College of Medical Sciences and GTB Hospital, Dilshad Garden, Delhi 110-095, India.
Clinical and Experimental Dermatology
|January 16, 2004
Summary
This case study highlights Rowell's syndrome, a rare condition linking systemic lupus erythematosus with erythema multiforme-like lesions and specific antibodies. It also suggests a co-occurring antiphospholipid syndrome in a young pregnant woman.
Area of Science:
- Rheumatology
- Immunology
- Dermatology
Background:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease.
- Rowell's syndrome is a rare condition characterized by SLE, erythema multiforme-like lesions, and a specific immunological profile.
- Antiphospholipid syndrome (APS) involves blood clots and pregnancy complications.
Observation:
- A 27-year-old primigravida presented with features suggestive of Rowell's syndrome.
- The patient exhibited erythema multiforme-like skin lesions.
- Immunological findings included antinuclear antibody (speckled pattern) and rheumatoid factor.
Findings:
- The patient's presentation was consistent with Rowell's syndrome.
- Laboratory tests indicated a probable antiphospholipid syndrome.
- Key indicators for APS included prolonged activated partial thromboplastin time, kaolin clotting time, and thrombocytopenia.
Implications:
- This case underscores the importance of recognizing rare autoimmune associations.
- Co-occurrence of Rowell's syndrome and antiphospholipid syndrome requires careful management, especially in pregnancy.
- Further research into the interplay of these conditions is warranted.