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Related Experiment Videos

Does solitary morphoea profunda progress?

J Azad1, G Dawn, F C G Shaffrali

  • 1Department of Dermatology, Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, Scotland, UK. gmitali@eggconnect.net

Clinical and Experimental Dermatology
|January 16, 2004
PubMed
Summary

Solitary morphoea profunda (SMP) is a rare scleroderma form. This report details three female cases with buttock lesions, challenging the nonprogressive nature of SMP.

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Area of Science:

  • Dermatology
  • Rheumatology
  • Scleroderma Research

Background:

  • Solitary morphoea profunda (SMP) is an uncommon variant of localized scleroderma.
  • SMP is infrequently documented, with the trunk's back typically cited as the most frequent site.
  • The condition has historically been considered nonprogressive.

Observation:

  • This report presents three SMP cases observed within a single year.
  • All three patients were female, with lesions located on the right upper buttock.
  • One patient experienced lesion extension despite initial treatment with topical tacrolimus.

Findings:

  • The typical presentation of SMP involves the trunk's back, but these cases highlight buttock involvement.
  • The observed cases challenge the established understanding of SMP as a nonprogressive condition.

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  • Topical clobetasol propionate proved effective in controlling lesion extension after topical tacrolimus failed.

    • Implications:

    • These findings suggest SMP may present atypically and potentially exhibit progressive behavior.
    • Further research is warranted to understand the variable clinical course and optimal management of SMP.
    • This case series contributes to the limited literature on solitary morphoea profunda, emphasizing the need for broader clinical awareness.