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Published on: October 19, 2014
[Hepatosplenic gammadeltaT-cell lymphoma: a clinicopathological study]
Jian Geng1, Mei-gang Zhu, Yan-qing Ding
1Department of Pathology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China. geng@fimmu.com
Objective:
To explore the clinicopathologic features and immunophenotype of hepatosplenic gammadeltaT-cell lymphoma.
Methods:
A case of hepatosplenic gammadeltaT-cell lymphoma was studied with conventional histopathological and immunohistochemical staining in combination of literature review.
Results:
Diffuse hepatic and splenic enlargement was found in this case. Microscopically, the liver and spleen showed marked sinusoidal infiltration. The cells of hepatosplenic T-cell lymphoma were homogeneous, medium in size with pale cytoplasm, and the nuclear chromatin was loosely condensed with small inconspicuous nucleoli. The neoplastic cells were positive for CD45RO, CD3 and TIA-1, but negative for CD57, CD20 and CD79a.
Conclusion:
Hepatosplenic gammadeltaT-cell lymphoma is a rare form of peripheral T-cell lymphoma and has usually poor prognosis, which should be differentiated from other lymphomas or leukemia.
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