Related Experiment Video

Updated: Aug 17, 2026

Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt
12:27

Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt

Published on: May 7, 2015

Is there disparity between risk and incidence of cardiovascular disease after liver transplant?

David A J Neal1, Brian D M Tom, Jian'an Luan

  • 1Department of Medicine, University of Cambridge, School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK.

Transplantation
|January 16, 2004
PubMed

Insights

Liver transplant recipients face increased risks for cardiovascular disease due to hypertension and hypercholesterolemia. Despite higher predicted coronary heart disease risk, no deaths from heart attack or stroke occurred in the study.

Area of Science:

  • Cardiology
  • Hepatology
  • Transplantation Medicine

Background:

  • Hypertension and hypercholesterolemia are known complications post-liver transplantation.
  • The impact of these complications on cardiovascular disease (CVD) development remains unclear.

Purpose of the Study:

  • To determine the prevalence of coronary heart disease (CHD) risk factors after liver transplantation.
  • To assess the effect of liver transplantation on predicted 10-year CHD risk and cardiovascular event incidence compared to a matched population.

Main Methods:

  • Retrospective analysis of 181 adult liver transplant recipients.
  • Data collected included blood pressure, lipids, weight, diabetes, smoking, myocardial infarction (MI), and stroke.
  • Framingham coronary risk equations were used to calculate 10-year CHD risk.

Main Results:

  • Prevalence of hypertension was 77%; hypercholesterolemia was 62%.
  • Predicted 10-year CHD risk increased from 6.9% pre-transplant to 11.5% post-transplant, versus 7% in controls.
  • Incidence ratios for MI and stroke were 0.55 and 1.45, respectively, compared to non-transplant controls.

Conclusions:

  • Liver transplant recipients exhibit a high prevalence of CVD risk factors and elevated predicted CHD risk.
  • Despite increased risk factors, no deaths from CHD or stroke were observed during the follow-up period.
Abstract

More Related Videos

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation08:39

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

Published on: November 7, 2020

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model12:49

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model

Published on: August 17, 2022

Related Concept Videos

Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug binding...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...