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Dopamine transporter binding in Gilles de la Tourette syndrome: a [123I]FP-CIT/SPECT study
J Serra-Mestres1, H A Ring, D C Costa
1Department of Neuropsychiatry, Institute of Neurology, University College London, UK. jordi.serra-mestres@thh.nhs.uk
Objective:
To investigate dopamine transporter binding in Gilles de la Tourette syndrome (GTS) with SPECT and [123I]FP-CIT.
Method:
Ten neuroleptic naïve/free patients with GTS, and 10 age- and gender-matched normal volunteers were studied. Subjects were clinically evaluated. GTS severity and affective symptoms were measured and the presence of GTS-related behaviours were recorded.
Results:
The GTS group showed significantly higher binding in both caudate and putamen nuclei than the controls. No associations were found between striatal binding ratios and measures of affect or GTS-related behaviours.
Conclusion:
Patients with GTS show higher striatal binding of FP-CIT to the striatum in comparison with age- and gender-matched control subjects, indicating that dopamine transporter abnormalities are involved in the pathophysiology of GTS. These abnormalities appear to be distributed across both caudate and putamen.
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