Cerebellar metabolite alterations detected in vivo by proton MR spectroscopy
M A Macrì1, G Garreffa, F Giove
1Dipartimento di Medicina Sperimentale e Patologia, Università, La Sapienza, di Roma, Rome, Italy.
Abstract:
The aim of our work was to evaluate the feasibility of in vivo single-voxel quantitative proton MR spectroscopy in order to identify possible alterations in the main metabolite concentrations due to some metabolic dysfunctions in the cerebellum of patients suffering from a particular form of migraine called "with aura." Measurements of metabolite levels in the cerebellum disclosed reduced choline values (normalized both to N-acetyl-aspartate and creatine) in the patient group with respect to the age-matched control group. Our interest in this pathology is motivated by the fact that there are no available specific biochemical markers for migraine characterization, and the current diagnostic only takes advantage of the medical history and the clinical examination.
More Related Videos
Related Concept Videos
Proton (¹H) NMR: Chemical Shift
Absorption signals of all the protium nuclei in a...
NMR Spectroscopy and Mass Spectrometry of Aldehydes and Ketones
¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)
¹H NMR of Labile Protons: Deuterium (²H) Substitution
¹H NMR of Labile Protons: Temporal Resolution
The –OH proton in alcohols typically appears in the range of δ 2 to 5 ppm but can vary depending on the specific...
¹H NMR: Complex Splitting
Splitting diagrams or splitting tree diagrams are routinely used to depict such complex couplings. While drawing splitting diagrams, the splitting with the larger coupling constant is usually applied first.


