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The physicochemical characteristics and bioavailability of indomethacin from beta-cyclodextrin,
Sunil Jambhekar1, R Casella, T Maher
1Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, 179 Longwood Avenue, Boston, MA 02115, USA.
International Journal of Pharmaceutics
|January 17, 2004
Abstract:
In an effort to improve the bioavailability of the insoluble drug indomethacin, three complexes were prepared with indomethacin and the soluble complexing agents beta-, hydroxyethyl-beta-, and hydroxypropyl-beta-cyclodextrin. The indomethacin content was similar among the complexes (P