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Updated: Aug 29, 2026

An In Vivo Assessment of Blood-Brain Barrier Disruption in a Rat Model of Ischemic Stroke
Published on: March 11, 2018
Blood pressure decrease during the acute phase of ischemic stroke is associated with brain injury and poor stroke
José Castillo1, Rogelio Leira, María M García
1Department of Neurology, Hospital Clínico Universitario, University of Santiago de Compostela, Spain. mecasti@usc.es
Background And Purpose:
Studies on the relation between blood pressure (BP) and stroke outcome have shown contradictory results. We explored the association of systolic (SBP) and diastolic (DBP) BP during acute stroke with early neurological deterioration, infarct volume, neurological outcome, and mortality at 3 months.
Methods:
We included 304 patients with acute ischemic stroke. SBP and DBP on admission and on the first day were the average values of all readings obtained in the emergency department and during a 24-hour period after patient allocation in the stroke unit.
Results:
A U-shaped effect was observed: for every 10 mm Hg
Conclusions:
High and low SBP and DBP, as well as a relevant drop in BP, are associated with poor prognosis in patients with ischemic stroke.
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