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Regulatory (suppressor) T cells in peripheral allograft tolerance and graft-versus-host reaction

Gérard Rifle1, Patrick Hervé

  • 1UPRES EA563, Faculté de Médecine, Université de Bourgogne and Department of Nephrology-Intensive Care-Transplantation, Hôpital du Bocage, Dijon, France. gerard.rifle@chu-dijon.fr.

Transplantation
|January 17, 2004
PubMed

Among the mechanisms capable of inducing peripheral tolerance, regulatory (suppressor) T cells (Treg) probably play a key role in the control of both reactivity to self-antigens and alloimmune response. Augmentation or manipulation of Treg could improve organ allograft survival or control graft-versus-host disease, thus resulting in operational tolerance. The role of this immunomanipulation as one method of inducing tolerance has yet to be clearly defined.

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