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Intraneural dendritic cell neurofibroma with pseudorosettes
Dmitry V Kazakov1, Petr Mukensnabl, Michal Zamecnik
1Sikl's Department of Pathology, Charles University, Medical Faculty Hospital, Pilsen, Czech Republic.
The American Journal of Dermatopathology
|January 17, 2004
Summary
Dendritic cell neurofibroma with pseudorosettes (DCNWPR) is a rare nerve sheath tumor. Our findings suggest DCNWPR originates from peripheral nerves, not melanocytic cells, clarifying its classification.
Area of Science:
- Dermatopathology
- Oncology
- Nerve Sheath Tumors
Background:
- Dendritic cell neurofibroma with pseudorosettes (DCNWPR) is a recently described variant of neurofibroma.
- Its classification and origin have been debated, with suggestions of melanocytic nevus with neural differentiation.
Observation:
- We present a case of DCNWPR.
- The tumor was observed to arise almost exclusively within the perineurium of cutaneous nerves.
Findings:
- The perineurial origin provides strong evidence for DCNWPR being a peripheral nerve sheath tumor.
- This finding refutes the hypothesis that DCNWPR is related to melanocytic neoplasms.
Implications:
- This study clarifies the histogenesis of DCNWPR.
- It supports the classification of DCNWPR as a peripheral nerve sheath tumor, distinct from melanocytic lesions.