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Bacterial adherence to human gallbladder epithelium.

S Sakurai1, N Shinagawa, T Fukui

  • 1First Department of Surgery, Nagoya City University Medical School, Japan.

Surgery Today
|January 1, 1992
PubMed
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Bacterial adherence to gallbladder epithelium increases with cholecystitis severity. Normal epithelium inhibits bacterial adhesion, suggesting secondary infections are more likely with epithelial damage and contaminated bile.

Area of Science:

  • Gastroenterology
  • Microbiology
  • Pathology

Background:

  • Gallbladder infections are common in cholecystitis.
  • The role of epithelial integrity in bacterial adherence is not fully understood.

Purpose of the Study:

  • To quantify the adherence of Escherichia coli and Pseudomonas aeruginosa to gallbladder epithelium in varying stages of cholecystitis.
  • To correlate bacterial adherence with the degree of epithelial damage.

Main Methods:

  • Scanning electron microscopy was used to quantify bacterial adherence.
  • Gallbladder tissues were obtained from 32 patients categorized into normal, chronic calculus cholecystitis, and acute calculus cholecystitis groups.

Main Results:

  • Bacterial adherence of both E. coli and P. aeruginosa was significantly higher in acute calculus cholecystitis compared to chronic and normal groups.

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  • Adherence was also significantly higher in the chronic group versus the normal group.
  • Bacterial adherence correlated positively with the extent of epithelial damage.

    • Conclusions:

    • Gallbladder epithelial damage increases susceptibility to bacterial infections like E. coli and P. aeruginosa.
    • Normal gallbladder epithelium exhibits an inhibitory effect on bacterial adherence.
    • Treatment for acute cholecystitis should consider bile culture results or predictive factors for bactibilia to manage secondary bacterial infections effectively.