Evaluation of quick disintegrating calcium carbonate tablets
Related Experiment Video
Updated: Aug 29, 2026

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
H Fausett1, C Gayser, A K Dash
1Department of Pharmaceutical & Administrative Sciences, School of Pharmacy & AHP, Creighton University, Omaha, NE 68178, USA.
Abstract:
The purpose of this investigation was to develop a rapidly disintegrating calcium carbonate (CC) tablet by direct compression and compare it with commercially available calcium tablets. CC tablets were formulated on a Carver press using 3 different forms of CC direct compressed granules (Cal-Carb 4450, Cal-Carb 4457, and Cal-Carb 4462). The breaking strength was measured using a Stokes-Monsanto hardness tester. The disintegration and dissolution properties of the tablets were studied using USP methodology. The calcium concentration was determined by an atomic absorption spectrophotometer. Scanning electron microscopy was used to evaluate the surface topography of the granules and tablets. Breaking strength of Cal-Carb 4450, Cal-Carb 4457, and Cal-Carb 4462 tablets was in the range of 7.2 to 7.7 kg, as compared with a hardness of 6.2 kg and 10 kg for the commercially available calcium tablets Citracal and Tums, respectively. The disintegration time for the tablets presented in the order earlier was 4.1, 2.1, 1.9, 2.9, and 9.7 minutes, respectively. The dissolution studies showed that all formulations released 100% of the elemental calcium in simulated gastric fluid in less than 20 minutes. In summary, this study clearly demonstrated that quick disintegrating CC tablets can be formulated without expensive effervescence technology.
Related Concept Videos
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules
Factors Influencing Drug Absorption: Pharmaceutical Parameters
In Vitro Drug Dissolution: Compendial Testing Models I
Drug Dissolution: Requirements and Profile Comparison
In Vitro Drug Dissolution: Alternative Methods
Modified-Release Drug Delivery Systems: Rate-Programmed I

