Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Ziprasidone and cognition: the evolving story.

Philip D Harvey¹

¹Department of Psychiatry, Mt. Sinai School of Medicine, New York University, New York 10029, USA. PDHarvey@compuserve.com

The Journal of Clinical Psychiatry

|January 20, 2004

Summary

Ziprasidone, an atypical antipsychotic, significantly improved cognitive functions in schizophrenia patients. These cognitive enhancements may lead to better social engagement and overall patient outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Comparisons of Self-Report With Objective Measurements Suggest Faster Responding but Little Change in Response Quality Over Time in Ecological Momentary Assessment Studies.

Assessment·2024

Same author

The MATRICS consensus cognitive battery for the assessment of cognitive impairment in schizotypal personality disorder.

Schizophrenia research·2024

Same author

Relationships between Sleep Quality, Introspective Accuracy, and Confidence Differ among People with Schizophrenia, Schizoaffective Disorder, and Bipolar Disorder with Psychotic Features.

Behavioral sciences (Basel, Switzerland)·2024

Same author

Current and Emerging Technologies to Address the Placebo Response Challenge in CNS Clinical Trials: Promise, Pitfalls, and Pathways Forward.

Innovations in clinical neuroscience·2024

Same author

Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder.

Molecular psychiatry·2024

Same author

A meta-cognitive Wisconsin Card Sorting Test in people with schizophrenia and bipolar disorder: Self-assessment of sorting performance.

Psychiatry research·2024

Area of Science:

Neuroscience
Psychiatry
Pharmacology

Background:

Cognitive impairment is a core feature of schizophrenia, impacting daily functioning.
Antipsychotic medications are being investigated for their cognitive benefits in schizophrenia.
Atypical antipsychotics generally show greater cognitive improvements than conventional agents.

Purpose of the Study:

To review the effects of the atypical antipsychotic ziprasidone on cognitive function in schizophrenia.
To analyze recent data from comparative and switching studies involving ziprasidone.

Main Methods:

A comparative trial of ziprasidone versus olanzapine.
Three studies involving patients switched to ziprasidone due to inadequate response to other antipsychotics.
Analysis of cognitive domains including episodic memory, attention, executive function, and visuomotor speed.

Main Results:

Ziprasidone treatment led to significant improvements in multiple cognitive domains.
Improvements were observed in episodic memory, attention/vigilance, executive function, and visuomotor speed.
In switching studies, cognitive improvements correlated with reduced anxiety-depression symptoms and enhanced social engagement.

Conclusions:

Ziprasidone demonstrates efficacy in improving cognitive function in schizophrenia patients.
These cognitive benefits may positively influence functional outcomes and social engagement.
Further research into ziprasidone's long-term impact on patient outcomes is warranted.

Related Experiment Videos