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Updated: Jul 31, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
Integrating pharmacokinetics knowledge into a drug ontology: as an extension to support pharmacogenomics
C G Chute1, J S Carter, M S Tuttle
1Division of Medical Informatics Research, Mayo Clinic, Rochester, MN, USA.
Abstract:
The newly developed U.S. Common Medication Information Infrastructure was used as a basis to capture and formally express the properties of drugs relevant to research and the clinical application of pharmacogenomics. Two associated taxonomies within the model, Mechanism of Action and Physiologic Effect, were enriched to accommodate pharmacogenomic use-cases; the 4,000 active ingredients in the VA NDF-RT drug file were related to the enhanced taxonomies. Pharmacokinetics were independently modeled for pharmacogenomics and tested against thirty-one high-profile drugs to demonstrate our approach.
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