Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Expression array annotation using the BioMediator biological data integration system and the BioConductor analytic

H Mei1, P Tarczy-Hornoch, P Mork

  • 1Biomedical & Health Informatics, University of Washington, Seattle, WA, USA.

AMIA ... Annual Symposium Proceedings. AMIA Symposium
|January 20, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Correlation of per- and polyfluoroalkyl substances exposure with gestational age acceleration and birth outcomes in monozygotic twins].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2026
Same author

[Current status and progress of prognostic evaluation in marginal zone lymphoma].

Zhonghua yi xue za zhi·2026
Same author

First Evidence for Mixing-Induced CP Violation in B_{s}^{0}→J/ψϕ(1020) Decays in pp Collisions at sqrt[s]=13  TeV.

Physical review letters·2026
Same author

[The application of thrombopoietin receptor agonists in the treatment of non-muscle myosin heavy chain 9-related disease].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2026
Same author

Measurement of D^{0} Meson Photoproduction in Ultraperipheral Heavy Ion Collisions.

Physical review letters·2026
Same author

Observation of Coherent ϕ(1020) Meson Photoproduction in Ultraperipheral PbPb Collisions at sqrt[s_{NN}]=5.36  TeV.

Physical review letters·2026
Same journal

Sensitivity Analyses of a Scoring System for a Contraception Decision Aid.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
Same journal

Improving electronic health record processing of large language models via retrieval-augmented generation: A case study on dietary supplements.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
Same journal

Developing a User-Centered Mobile Application Prototype: Bridging Lower-Limb Fracture Care from Skilled Nursing Facility and Back to the Community.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
Same journal

KERAP: A Knowledge-Enhanced Reasoning Approach for Accurate Zero-shot Diagnosis Prediction Using Multi-agent LLMs.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
Same journal

Automating Adjudication of Cardiovascular Events Using Large Language Models.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
Same journal

Predictive Factors and State-Level Barriers to Postpartum Birth Control Usage in the United States: Insights from PRAMS Phase 8.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
See all related articles

This study introduces an expression array annotation (EAA) model using BioMediator and BioConductor to enhance genomic data analysis. The developed system provides curated genomic knowledge for accurate interpretation of expression array data.

Area of Science:

  • Bioinformatics
  • Genomics
  • Computational Biology

Background:

  • Expression array analysis requires comprehensive genomic background knowledge for accurate interpretation.
  • Existing annotation resources presented challenges during the development of the BioConductor analytic tools platform.
  • A robust and integrated approach to biological data annotation is crucial for advancing genomic research.

Purpose of the Study:

  • To implement a novel model for expression array annotation (EAA).
  • To integrate the EAA model within the BioMediator biological data integration system and the BioConductor analytic tools platform.
  • To address the identified need for reliable annotation sources in genomic data analysis.

Main Methods:

  • Development of an expression array annotation (EAA) package as a component of BioConductor.

Related Experiment Videos

  • Utilization of the BioMediator system for biological data integration and query processing.
  • Construction and submission of annotation requests through the EAA package's query interface.
  • Enumeration of annotation paths and transformation into PQL queries for BioMediator.

    • Main Results:

    • Successful implementation of the EAA model integrated with BioMediator and BioConductor.
    • The system effectively enumerates all possible annotation paths for given queries.
    • Annotation entities retrieved from the EAA package successfully fulfill annotation requests.
    • Enhanced access to well-curated genomic background knowledge for expression array analysis.

    Conclusions:

    • The implemented EAA model provides a valuable solution for expression array annotation.
    • Integration with BioMediator and BioConductor enhances the utility and accessibility of genomic annotation data.
    • This approach supports more robust and reliable interpretation of expression array analysis results.
    • The developed system addresses a critical need in the field of genomic data interpretation.