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Updated: Aug 29, 2026
Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays
Published on: September 26, 2011
The use of data mining to investigate a possible quality problem with ultrasensitive HIV viral load data at a large
Eileen Koski1, Peter N R Heseltine, Ron M Kagan
1Quest Diagnostics Incorporated, Advanced Diagnostics IT, Teterboro, NJ, USA.
Abstract:
Suppression of HIV viral load to <50 copies/mL, the lower limit of detection for the ultrasensitive assays, has been shown to correlate with favorable clinical outcome. Patients periodically exhibited transient or sustained low-level viremia based on this test. In order to investigate a possible quality concern, we used our corporate data warehouse to examine the patterns in our data over time as well as across geographic regions.
