Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Building an application framework for integrative genomics.

Heta N Ray1, Vamsi K Mootha, Aziz A Boxwala

  • 1Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.

AMIA ... Annual Symposium Proceedings. AMIA Symposium
|January 20, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling.

PloS one·2026
Same author

Mechanism of age-related accumulation of mtDNA mutations in human blood.

Nature·2026
Same author

4,5-dihydroxyhexanoic acid is a robust circulating and urine marker of mitochondrial disease and its severity.

bioRxiv : the preprint server for biology·2026
Same author

Mitochondrial depolarization stabilizes the vitamin B12 chaperone MMADHC in the cytosol to increase MTR activity.

bioRxiv : the preprint server for biology·2026
Same author

Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency.

Nature·2025
Same author

The proton motive force maintains mtDNA euploidy by balancing mtDNA replication with cell proliferation.

bioRxiv : the preprint server for biology·2025
Same journal

Sensitivity Analyses of a Scoring System for a Contraception Decision Aid.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
Same journal

Improving electronic health record processing of large language models via retrieval-augmented generation: A case study on dietary supplements.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
Same journal

Developing a User-Centered Mobile Application Prototype: Bridging Lower-Limb Fracture Care from Skilled Nursing Facility and Back to the Community.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
Same journal

KERAP: A Knowledge-Enhanced Reasoning Approach for Accurate Zero-shot Diagnosis Prediction Using Multi-agent LLMs.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
Same journal

Automating Adjudication of Cardiovascular Events Using Large Language Models.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
Same journal

Predictive Factors and State-Level Barriers to Postpartum Birth Control Usage in the United States: Insights from PRAMS Phase 8.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
See all related articles

New software architecture enables researchers to explore vast genomic data, uncovering new biological relationships and functional insights efficiently. This bioinformatics tool facilitates data integration for deeper understanding.

Area of Science:

  • Bioinformatics
  • Genomics
  • Computational Biology

Background:

  • Biological research is accelerating, generating large-scale genomic datasets.
  • Existing data exploration tools lack flexibility for integrating diverse biological information.

Purpose of the Study:

  • To design a software architecture for querying and exploring large biological datasets.
  • To create an extensible platform for web-based bioinformatics applications.
  • To enable users to discover new functional relationships within disparate data sources.

Main Methods:

  • Developed a novel software architecture and framework.
  • Focused on an orderly and iterative approach to data querying.
  • Designed for end-user extensibility and integration of various data types.

Related Experiment Videos

Main Results:

  • An extensible platform for bioinformatics application development.
  • A flexible software environment for data exploration and integration.
  • Facilitation of the discovery of existing and novel biological relationships.

Conclusions:

  • The designed architecture supports efficient exploration of genomic data.
  • The framework enhances the integration of disparate biological datasets.
  • Enables researchers to uncover new functional insights from complex biological data.