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Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
Published on: April 7, 2023
The progesterone antagonist, RU486 does not affect basal or estrogen-stimulated cancellous bone formation in the rat
1Histopathology Department, St George's Hospital Medical School, London, UK.
Bone and Mineral
|December 1, 1992
Summary
Progesterone does not influence estrogen
Area of Science:
- Bone biology and endocrinology.
Background:
- Estrogen therapy is used to prevent postmenopausal bone loss, but progesterone's role is unclear.
- High-dose estrogen stimulates bone formation in rats, but progesterone's effect on this action is unknown.
Purpose of the Study:
- To investigate the role of progesterone in combination with estrogen on bone formation and growth in rats.
Main Methods:
- Wistar female rats were treated with RU486 (progesterone antagonist) and/or estrogen.
- Histomorphometric indices of bone formation and longitudinal bone growth were measured.
Main Results:
- RU486 alone did not alter bone formation or growth.
- Estrogen significantly increased bone formation and inhibited longitudinal growth.
- RU486 did not affect estrogen's anabolic or inhibitory actions on bone.
Conclusions:
- Progesterone does not appear to play a significant role in estrogen-mediated bone formation or growth in rats.
