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Characterization of glomerular angiotensin II receptor subtypes
1Laboratory of Experimental Hypertension and Vasoactive Peptides, Clinical Research Institute of Montreal, Quebec, Canada.
Receptor
|January 1, 1992
Abstract:
Radioligand-receptor binding techniques identified two angiotensin II (ANG II) receptor subtypes in rat renal glomerular membranes. This characterization was made possible by employing two highly-specific nonpeptide ANG II antagonists: Losartan (DuP 753), which is specific to the AT1 subtype, and PD 123319, which is specific to the AT2 subtype. The majority of ANG II receptors in glomerular membranes corresponded to the AT1 subtype.