Intracranial infection associated with preseptal and orbital cellulitis in the pediatric patient
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Published on: February 9, 2011
Dorothy J Reynolds1, Sylvia R Kodsi, Steven E Rubin
1Department of Ophthalmology, North Shore--Long Island Jewish Health System, Great Neck, NY, USA.
Insights
Children with preseptal or orbital cellulitis and signs like headache or fever may have intracranial infections. Prompt diagnosis and broad-spectrum antibiotics are crucial for managing these serious pediatric infections.
Area of Science:
- Pediatric infectious diseases
- Ophthalmology
- Neurosurgery
Background:
- Preseptal and orbital cellulitis are common pediatric infections.
- Intracranial complications can arise from these infections, necessitating prompt recognition and management.
Purpose of the Study:
- To identify risk factors associated with intracranial infections in children diagnosed with preseptal or orbital cellulitis.
- To improve diagnostic and treatment strategies for pediatric patients with these conditions.
Main Methods:
- Retrospective chart review of 10 pediatric patients (<= 18 years) with preseptal/orbital cellulitis and intracranial infection.
- Analysis of diagnoses, microbial cultures, and treatment interventions.
Main Results:
- Common diagnoses included sinusitis, orbital subperiosteal abscess, Pott's puffy tumor, epidural empyema/abscess, and brain abscess.
- Polymicrobial infections (Streptococcus, Staphylococcus) were frequent, requiring broad-spectrum antibiotics.
- All patients needed medical and surgical treatment, including sinus surgery, craniotomy, and orbital surgery.
Conclusions:
- Suspect intracranial involvement in children >= 7 years with orbital cellulitis, sinusitis, headache, or persistent fever.
- Broad-spectrum antibiotics are indicated due to high rates of polymicrobial infections.
- Include brain imaging when evaluating orbits and sinuses to rule out intracranial spread.
Purpose:
To identify risk factors in children admitted with preseptal or orbital cellulitis with associated intracranial infection.
Methods:
A retrospective chart review identified 10 patients (< or = 18 years) with a diagnosis of preseptal or orbital cellulitis and a concurrent or subsequent diagnosis of intracranial infection.
Results:
Diagnoses confirmed by imaging included sinusitis (n = 10), preseptal cellulitis (n = 4), orbital cellulitis (n = 6), orbital subperiosteal abscess (n = 5), Pott's puffy tumor (n = 4), epidural empyema (n = 2), epidural abscess (n = 6), and brain abscess (n = 2). The timing of diagnosis of intracranial infection ranged from hospital day 1 to 21. All but 1 patient had positive microbial cultures. Seven of 10 patients had positive microbial cultures from two or more sites, 70% of which were polymicrobial; Streptococcus species and Staphylococcus species were the most commonly isolated bacterial pathogens. All patients required both medical and surgical therapy; all 10 patients underwent sinus surgery; 8 patients required neurosurgical craniotomy; and 5 patients underwent orbital surgery. There were no deaths.
Conclusion:
Intracranial involvement should be suspected in any patient age > or = 7 years with preseptal or orbital cellulitis associated with orbital subperiosteal abscess, Pott's puffy tumor, concurrent sinusitis, complaints of headache, and continuing fever despite intravenous antibiotics. Given the high incidence of polymicrobial infection found on cultures in this series, broad-spectrum antibiotics are strongly indicated. When imaging the orbits and sinuses in such patients, we recommend including the brain to rule out intracranial involvement.
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