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Voiding dysfunction in women with systemic lupus erythematosus.

Hong-Jeng Yu1, Wei-Chia Lee, Kuang-Lun Lee

  • 1National Taiwan University, Taipei, Taiwan. yhj5251@ha.mc.ntu.edu.tw

Arthritis and Rheumatism
|January 20, 2004
PubMed
Summary

Women with systemic lupus erythematosus (SLE) have higher rates of bladder dysfunction, including urinary frequency and urgency. This voiding dysfunction may stem from direct bladder issues or other factors related to SLE.

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Area of Science:

  • Urology
  • Rheumatology
  • Nephrology

Background:

  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect multiple organ systems.
  • Bladder dysfunction is a potential complication of SLE, impacting quality of life.

Purpose of the Study:

  • To investigate the prevalence and characteristics of bladder dysfunction in women with SLE.
  • To compare lower urinary tract symptoms in SLE patients with a healthy control group.

Main Methods:

  • Prospective study of 152 female SLE patients and 227 age-matched healthy controls over 15 months.
  • Assessment of SLE disease activity using SLE Disease Activity Index (SLEDAI).
  • Evaluation of bladder function via lower urinary tract symptoms (using adapted AUA index) and urodynamic studies.

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Main Results:

  • SLE patients reported significantly higher rates of urinary frequency, urgency, weak stream, and incomplete emptying compared to controls.
  • Severe lower urinary tract symptoms (AUA index score ≥20) were more prevalent in the SLE group.
  • AUA index scores correlated modestly with SLEDAI (r=0.35, P<0.001) and were associated with central nervous system involvement.
  • Common urodynamic findings included small bladder capacity (<150 ml) and subnormal urinary flow rate (<12 ml/s).
  • Contracted bladder with hydroureteronephrosis was observed in some patients with small bladder capacity.

Conclusions:

  • Women with SLE exhibit an increased prevalence of voiding dysfunction.
  • Bladder dysfunction in SLE may result from direct bladder pathology or other systemic disease-related factors.