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Related Experiment Videos

[Studies on diclofenac sodium pulsatile release pellets].

Tao Guo1, Chun-li Zheng, Hong-tao Song

  • 1Department of Pharmacy, General Hospital of Shenyang Military Region, Shenyang 110016, China. guotao@mail.sy.ln.cn

Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|January 21, 2004
PubMed
Summary

Diclofenac sodium pulsatile release pellets (DS-PRP) demonstrate effective pulsed drug delivery. This formulation shows a delayed release in vitro and in vivo, achieving good bioavailability.

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Pharmacokinetics

Background:

  • Pulsatile drug delivery systems offer advantages for chronopharmacology.
  • Diclofenac sodium is a widely used non-steroidal anti-inflammatory drug.

Purpose of the Study:

  • To develop and characterize diclofenac sodium pulsatile release pellets (DS-PRP).
  • To evaluate the in vitro drug release and in vivo pharmacokinetics of DS-PRP.

Main Methods:

  • Pellets prepared using extrusion-spheronization and coated with swelling and controlled-release layers.
  • In vitro release studies conducted under varying conditions.
  • In vivo pharmacokinetic and bioavailability assessment in human subjects using HPLC.

Main Results:

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  • Formulation parameters significantly influenced delayed-release time and release rate.
  • In vitro: delayed-release time (T0.1) of 3.1 h, pulsed-release time (T0.1-0.2) of 1.2 h.
  • In vivo: delayed-release time (Tlag) of 2.8 h, bioavailability of (91 ± 12)%.

Conclusions:

  • DS-PRP successfully achieved pulsatile drug release both in vitro and in vivo.
  • The developed system demonstrates potential for controlled pulsatile delivery of diclofenac sodium.