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[Stability studies of sulfated polyguluronic acid ester]
Zhen-qing Zhang1, Xia Zhao, Hua-shi Guan
1Marine Drug and Food Institute, Ocean University of Qing Dao, Qingdao 266003, China. zzq0127@hotmail.com
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|January 21, 2004
Summary
Marine polysaccharide sulfated polyguluronic acid ester demonstrates good stability. Testing confirmed its resilience under various conditions, with minor impact only at high temperatures.
Area of Science:
- Marine biotechnology
- Biopolymer chemistry
- Pharmaceutical analysis
Context:
- Marine polysaccharides are a growing area of interest for drug development.
- Sulfated polyguluronic acid ester is a promising marine-derived compound.
- Assessing drug stability is crucial for pharmaceutical applications.
Purpose:
- To evaluate the stability of sulfated polyguluronic acid ester.
- To establish reliable analytical methods for stability testing.
- To determine the compound's shelf-life under various stress conditions.
Summary:
- Four analytical methods (HPGC, PAGE, UV-Vis, gelatin nephelometry) were developed to assess stability.
- Samples were subjected to high temperature, humidity, light, and accelerated testing.
- The marine polysaccharide drug showed good stability, with notable changes only at high temperatures.
Impact:
- The established methods provide a framework for future stability studies of similar compounds.
- Findings support the potential of sulfated polyguluronic acid ester as a stable pharmaceutical agent.
- Understanding stability parameters is key to optimizing formulation and storage of marine-derived drugs.