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Published on: April 11, 2014
Dynamics of antioxidant action of vitamin E
1Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 563-8577, Japan. etsuo-niki@aist.go.jp
Abstract:
Vitamin E is the major lipophilic, radical-scavenging antioxidant in vivo and protects humans from the oxidative stress mediated by active oxygen and nitrogen species. The mechanisms of the inhibition of oxidation by vitamin E in vitro are now fairly well understood, but the dynamics of antioxidant action of vitamin E in vivo have not been well elucidated yet, primarily because of the inherent heterogeneity of biological systems. In this Account, the factors which determine the antioxidant capacity of vitamin E are discussed, and the importance of its localization and mobility in the membranes and lipoproteins is emphasized.
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